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Scientific References

References for Dr. Tanelian's Book Molecular Fitness: The Connexin Connection to Optimal Health

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Serum cortisol in the white-coat phenomenon.

Saito I I, Takeshita E, Murata K, Kawabe H, Saruta T.

Health Centre, Department of Medicine, Keio University, Tokyo, Japan.

BACKGROUND: The rise in blood pressure associated with a clinic visit (the white-coat phenomenon) may result from anxiety or an alerting reaction. There is evidence to suggest that glucocorticoids may be involved in the mechanism of stress-related blood pressure elevation, but the relationship between the white-coat phenomenon and glucocorticoids has not been assessed. DESIGN: Forty-eight young subjects with essential hypertension were compared with 12 control normotensive subjects. METHODS: Home blood pressure monitoring for 7 days and serum cortisol at 0900 h and 2 h rest at 1100 h were measured. The white-coat phenomenon was calculated for systolic and diastolic blood pressure and average home blood pressure. RESULTS: The serum cortisol level was significantly greater at 0900 h than that at 1100 h in the hypertensive subjects and was higher in the hypertensive subjects than in the normotensive subjects (21.5 +/- 0.5 versus 14.3 +/- 0.9 microg/dl), but there was no difference between serum cortisol levels at 1100 h in the two groups. The magnitude of the white-coat phenomenon, which was greater in the hypertensive subjects than in the normotensive group (22 +/- 2/12 +/- 1 versus 4 +/- 3/1 +/- 3 mmHg), correlated with serum cortisol at 0900 h, but not at 1100 h. The higher level of serum cortisol at 0900 h was confirmed by another measurement conducted 4 months later in a subsample of the hypertensive subjects ( n = 18). CONCLUSIONS: These results suggest that the white-coat phenomenon is related to the transient increase in serum cortisol or psychological stress, or both, which can trigger arousal of the hypothalamic pituitary adrenocortical axis.

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